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石曜嘉

Assistant Professor

📍 辦公室位置:元智三館3709室
📞 03-4638800轉6612
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EDUCATION

  • Institute of Biomedical Engineering, National Taiwan University, Taiwan - Ph.D. Sep 2010 - Jan 2019 National Taiwan
  • Normal University, Taiwan - M.S. Sep 2007 - Jun 2009
  • Yuan Ze University, Taiwan - B.S.

EXPERIENCE

  • Graduate Institute of Medicine, Yuan Ze University, Taiwan - Assistant Professor Aug 2021 - PRESENT
  • Principal Investigator at Clinical Neuroimaging and Neurocomputational Lab
  • Adjunct Assistant Professor at Department of Electrical Engineering (Program A)
  • Singapore General Hospital, Singapore - MR Physicist Sep 2019 - Jun 2021
  • Duke-NUS Medical School, Singapore - Postdoctoral Researcher Sep 2019 - Jun 2021
  • National Taiwan University Hospital, Taiwan - Postdoctoral Researcher Feb 2019 - Jun 2019
  • University of Aberdeen, Scotland, UK - Honorary Research Assistant

SKILLS

  • Magnetic Resonance Imaging, Neuroradiology, Neuroscience, Biomedical Engineering, Artificial Intelligence

PEER-REVIEWED JOURNAL PUBLICATIONS

  1. Huang YT, Yan SH, Chuang YF, Shih YC, Huang YS, Liu YC, Kao SSC, Chiu YL, Fan YT (2024). A mediating framework in resting-state connectivity between the medial prefrontal cortex and anterior cingulate in mild cognitive impairment. Aging Clinical and Experimental Research (in press).
  2. Hartono S, Chen RC, Welton T, Tan AS, Lee W, Teh PY, Chen C, Hou W, Tham WP, Lim EW, Prakash KM, Shih YC, Lee KJ, Tan LCS, Tan EK, Chan LL (2023). Quantitative iron-neuromelanin MRI associates with motor severity in Parkinson's disease and matches radiological disease classification. Frontiers in Aging Neuroscience 15:1287917. https://doi.org/10.3389/fnagi.2023.1287917
  3. Welton T, Hartono S, Shih YC, Schwarz ST, Xing Y, Tan EK, Auer DP, Harel N, Chan LL (2023). Ultra-High-Field 7T MRI in Parkinson's Disease: Ready for Clinical Use? A Narrative Review. Quantitative Imaging in Medicine and Surgery 13(11):7607-7620. https://doi.org/10.21037/qims-23-509
  4. Shih YC, Ooi LQR, Li HH, Allen JC, Hartono S, Welton T, Tan EK, Chan LL (2023). Serial deep gray nuclear DTI changes in Parkinson's disease over twelve years. Frontiers in Aging Neuroscience 15:1169254. https://doi.org/10.3389/fnagi.2023.1169254
  5. Welton T, Hartono S, Shih YC, Lee W, Chai PH, Chong SL, Ng SYE, Chia NSY, Choi X, Heng DL, Tan EK, Tan LCS, Chan LL (2023). Microstructure of Brain Nuclei in Early Parkinson's Disease: Longitudinal Diffusion Kurtosis Imaging. Journal of Parkinson's Disease 13(2):233-242. https://doi.org/10.3233/JPD-225095
  6. Welton T, Tan YJ, Saffari SE, Ng SYE, Chia NSY, Yong ACW, Choi X, Heng DL, Shih YC, Hartono S, Lee W, Xu Z, Tay KY, Au WL, Tan EK, Chan LL, Ng ASL, Tan LCS (2022). Plasma Neurofilament Light Concentration Is Associated with Diffusion-Tensor MRI-Based Measures of Neurodegeneration in Early Parkinson's Disease. Journal of Parkinson's Disease 12(7):2135-2146. https://doi.org/10.3233/JPD-223414
  7. Shih YC, Tseng WI, Montaser-Kouhsari L (2023). Recent advances in using diffusion tensor imaging to study white matter alterations in Parkinson's disease: A mini review. Frontiers in Aging Neuroscience 14:1018017. https://doi.org/10.3389/fnagi.2022.1018017
  8. Shih YC, Lin FH, Liou HH, Tseng WI (2021). Seizure Frequency Is Associated with Effective Connectivity of the Hippocampal-Diencephalic-Cingulate in Epilepsy with Unilateral Mesial Temporal Sclerosis. Brain Connectivity 11(6):457-470. https://doi.org/10.1089/brain.2020.0835
  9. Koh YH, Shih YC, Lim SL, Kiew YS, Lim EW, Ng SM, Ooi LQR, Tan WQ, Chung YC, Rumpel H, Tan EK, Chan LL (2021). Evaluation of trigeminal nerve tractography using two-fold-accelerated simultaneous multi-slice readout-segmented echo planar diffusion tensor imaging. European Radiology 31(2):640-649. https://doi.org/10.1007/s00330-020-07193-x
  10. Lee NC, Peng WH, Tsai LK, Lu YH, Wang HC, Shih YC, Pung ZX, Hu HY, Hwu WL, Tseng WI, Chien YH (2020). Ultrastructural and diffusion tensor imaging studies reveal axon abnormalities in Pompe disease mice. Scientific Reports 10(1):20239. https://doi.org/10.1038/s41598-020-77193-w
  11. Chen CL, Shih YC, Liou HH, Hsu YC, Lin FH, Tseng WI (2019). Premature white matter aging in patients with right mesial temporal lobe epilepsy: A machine learning approach based on diffusion MRI data. Neuroimage Clinical 24:102033. https://doi.org/10.1016/j.nicl.2019.102033
  12. Tsai TH, Su HT, Hsu YC, Shih YC, Chen CC, Hu FR, Tseng WI (2019). White matter microstructural alterations in amblyopic adults revealed by diffusion spectrum imaging with systematic tract-based automatic analysis. British Journal of Ophthalmology 103(4):511-516. https://doi.org/10.1136/bjophthalmol-2017-311733
  13. Shih YC, Tseng CE, Lin FH, Liou HH, Tseng WY (2017). Hippocampal Atrophy Is Associated with Altered Hippocampus-Posterior Cingulate Cortex Connectivity in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis. AJNR American Journal of Neuroradiology 38(3):626-632. https://doi.org/10.3174/ajnr.A5039
  14. Chien HY, Gau SS, Hsu YC, Chen YJ, Lo YC, Shih YC, Tseng WY (2015). Altered Cortical Thickness and Tract Integrity of the Mirror Neuron System and Associated Social Communication in Autism Spectrum Disorder. Autism Research 8(6):694-708. https://doi.org/10.1002/aur.1484
  15. Chang YL, Chen TF, Shih YC, Chiu MJ, Yan SH, Tseng WY (2015). Regional cingulum disruption, not gray matter atrophy, detects cognitive changes in amnestic mild cognitive impairment subtypes. Journal of Alzheimer's Disease 44(1):125-38. https://doi.org/10.3233/JAD-141839
  16. Lin YC, Shih YC, Tseng WY, Chu YH, Wu MT, Chen TF, Tang PF, Chiu MJ (2014). Cingulum correlates of cognitive functions in patients with mild cognitive impairment and early Alzheimer's disease: a diffusion spectrum imaging study. Brain Topography 27(3):393-402. https://doi.org/10.1007/s10548-013-0346-2

INVITED TALKS

  1. Advanced diffusion MRI in Parkinson's disease Academic Year Seminar at Department of Biomedical Engineering, National Yang Ming Chiao Tung University, 2021/09/30.
  2. Applications of MRI in neurological diseases National Taiwan University Hospital Yulin Branch International Neuroscience Symposium, 2022/03/25.
  3. Applications of structural and functional MRI in neurodegenerative diseases Department of Radiology, Taichung Veterans General Hospital, 2022/07/19.
  4. The use of structural MRI in Parkinson's disease Department of Medical Imaging, National Taiwan University Hospital, 2022/09/21.
  5. 擴散式磁振造影應用於高齡腦心智研究之發展現況 2023年高齡大腦心智科學X腦造影技術工作坊, 國立臺灣大學身體、心靈、文化整合影像研究中心主辦, 2023/05/05.
  6. 腦神經造影:結合電資工程與醫學的跨域技術 111學年度元智大學電機工程所甲組書報討論, 2023/05/17.
  7. 探勘新興巴金森氏症之核磁共振影像生物標記 111學年度元智大學資訊工程所書報討論, 2023/05/12.
2024
Low-intensity focused ultrasound with continuous theta burst stimulation induces human primary motor cortex functional connectivity changes
ISMRM & ISMRT Annual Meeting - Magna Cum Laude Merit Award (team)
PI
Investigating relationships between the trans-stenotic arteriovenous fistula/graft pressure gradient and the degrees of stenosis before/after percutaneous transluminal angioplasty in hemodialysis patients
YZU-FEMH grants 2023
PI
The Application of Normative MRI Data for Brain Structures in Visual System: A Case Study of Steven-Johnson Syndrome
YZU-FEMH grants 2023
Co-I
Advanced application of the low intensity focused ultrasound in neuromodulation—extended study
NHRI-112-H01. 2022-2023
PI
Using neuromelanin-sensitive and multi-shell diffusion MRI to investigate diagnostic imaging biomarkers in the brainstem nuclei for novel data-driven Parkinson's disease subtypes
NSTC-111-2222-E-155-002. 2021-2022
Co-I
Advanced application of the low intensity focused ultrasound in neuromodulation
NHRI-111-H02. 2021-2022
PI
High Angular Resolution Diffusion MRI Tractographic Atlas of Deep Axonal Projections and Its Application to Parkinson's Disease Connectometic Study
YZU-FEMH grants 2021
PI
Investigating relationships between the trans-stenotic arteriovenous fistula/graft pressure gradient and the degrees of stenosis before/after percutaneous transluminal angioplasty in hemodialysis patients
YZU-FEMH grants 2023
PI
The Application of Normative MRI Data for Brain Structures in Visual System: A Case Study of Steven-Johnson Syndrome
YZU-FEMH grants 2023
Co-I
Advanced application of the low intensity focused ultrasound in neuromodulation—extended study
NHRI-112-H01. 2022-2023
PI
Using neuromelanin-sensitive and multi-shell diffusion MRI to investigate diagnostic imaging biomarkers in the brainstem nuclei for novel data-driven Parkinson's disease subtypes
NSTC-111-2222-E-155-002. 2021-2022
Co-I
Advanced application of the low intensity focused ultrasound in neuromodulation
NHRI-111-H02. 2021-2022
PI
High Angular Resolution Diffusion MRI Tractographic Atlas of Deep Axonal Projections and Its Application to Parkinson's Disease Connectometic Study
YZU-FEMH grants 2021