Graduate Institute of Medicine, Yuan Ze University, Taiwan - Assistant Professor Aug 2021 - PRESENT

● Principal Investigator at Clinical Neuroimaging and Neurocomputational Lab
● Adjunct Assistant Professor at Department of Electrical Engineering (Program A)

Singapore General Hospital, Singapore - MR Physicist
Sep 2019 - Jun 2021

Duke-NUS Medical School, Singapore - Postdoctoral Researcher
Sep 2019 - Jun 2021

National Taiwan University Hospital, Taiwan - Postdoctoral Researcher
Feb 2019 - Jun 2019

University of Aberdeen, Scotland, UK - Honorary Research Assistant

Magnetic Resonance Imaging, Neuroradiology, Neuroscience, Biomedical Engineering, Artificial Intelligence

Institute of Biomedical Engineering, National Taiwan University, Taiwan - Ph.D. Sep 2010 - Jan 2019 National Taiwan

Normal University, Taiwan - M.S. Sep 2007 - Jun 2009

Yuan Ze University, Taiwan - B.S.

1. Low-intensity focused ultrasound with continuous theta burst stimulation induces human primary motor cortex functional connectivity changes. 2024 ISMRM & ISMRT Annual Meeting & Exhibition, 4-9 May 2024, Singapore. Magna Cum Laude Merit Award (team)

2. 使用類澱粉之 T細胞反應作為認知功能障礙之創新生物標記, 第二十屆 國家新創獎 (team)

3. Deep learning-based auscultation models for diagnosing arteriovenous fistula/graft stenosis assessed by angiography in hemodialysis patients. 14th AOCNR 31st SGCR 13th WIRES 2023, BEST WIRES Oral Awards (mentor)

4. Non-motor Correlates of Pedunculopontine Nucleus Projection Denervation in Parkinson’s Disease with Sleep Disturbances. 2023 ISMRM & ISMRT Annual Meeting & Exhibition, 3-8 Jun 2023, Toronto, Canada. Magna Cum Laude Merit Award (team)

5. 12-Year Microstructural Changes in The Deep Gray Nuclei in Parkinson’s Disease: A Serial Diffusion Tensor Imaging Study. ISMRM 2021. Summa Cum Laude Merit Award (1st author)

6. Seizure frequency in relation to effective connectivity of the hippocampal diencephalic-cingulate in temporal lobe epilepsy. ISMRM 2021. Magna Cum Laude Merit Award (1st author)

7. Microstructure of Grey Matter Nuclei in Early Parkinson’s Disease: Longitudinal Study using Diffusion Kurtosis Imaging. ISMRM 2021. Magna Cum Laude Merit Award (team)

8. Dopaminergic premotor and motor pathways are dominant in the progression of motor disability in Parkinson’s disease. ISMRM 2020. Summa Cum Laude Merit Award (1st author)

9. Trigeminal nerve tractography with accelerated simultaneous multislice readout-segmented echo planar diffusion tensor imaging. ISMRM 2020. Magna Cum Laude Merit Award (1st author)

10. Award of the 2nd Place in Oral Presentation. RADSC ACP Academic Day 2019 (1st author)

11. MOST Student Stipend: ISMRM 2016

12. MOST Student Stipend: OHBM 2011

1. PI. Investigating relationships between the trans-stenotic arteriovenous fistula/graft pressure gradient and the degrees of stenosis before/after percutaneous transluminal angioplasty in hemodialysis patients. YZU-FEMH grants 2023.

2. PI. The Application of Normative MRI Data for Brain Structures in Visual System: A Case Study of Steven-Johnson Syndrome. YZU-FEMH grants 2023.

3. Co-I. Advanced application of the low intensity focused ultrasound in neuromodulation—extended study. NHRI-112-H01. 2022-2023.

4. PI. Using neuromelanin-sensitive and multi-shell diffusion MRI to investigate diagnostic imaging biomarkers in the brainstem nuclei for novel data-driven Parkinson’s disease subtypes. NSTC-111-2222-E-155-002. 2021-2022.

5. Co-I. Advanced application of the low intensity focused ultrasound in neuromodulation. NHRI-111-H02. 2021-2022.

6. PI, High Angular Resolution Diffusion MRI Tractographic Atlas of Deep Axonal Projections and Its Application to Parkinson’s Disease Connectometic Study. YZU-FEMH grants 2021.

1. “Advanced diffusion MRI in Parkinson’s disease” in 2021 Academic Year Seminar at Department of Biomedical Engineering, National Yang Ming Chiao Tung University. 2021/09/30.

2. “Applications of MRI in neurological diseases” in National Taiwan University Hospital Yulin Branch International Neuroscience Symposium 2022. 2022/03/25.

3. "Applications of structural and functional MRI in neurodegenerative diseases" at Department of Radiology, Taichung Veterans General Hospital. 2022/07/19.

4. “The use of structural MRI in Parkinson’s disease” at Department of Medical Imaging, National Taiwan University Hospital. 2022/09/21.

5. “擴散式磁振造影應用於高齡腦心智研究之發展現況” 2023 年高齡大腦 心智科學 X 腦造影技術工作坊。國立臺灣大學身體、心靈、文化整合影 像研究中心主辦。2023/05/05.

6. “腦神經造影：結合電資工程與醫學的跨域技術”111 學年度元智大學電 機工程所甲組書報討論。2023/05/17.

7. "探勘新興巴金森氏症之核磁共振影像生物標記"111 學年度元智大學資 訊工程所書報討論。2023/05/12.

(†: Co-First Author)

1. Huang YT, Yan SH, Chuang YF, Shih YC, Huang YS, Liu YC, Kao SSC, Chiu YL, Fan YT. A mediating framework in resting-state connectivity between the medial prefrontal cortex and anterior cingulate in mild cognitive impairment. Aging Clinical and Experimental Research. 2024 (in press)

2. Hartono S, Chen RC, Welton T, Tan AS, Lee W, Teh PY, Chen C, Hou W, Tham WP, Lim EW, Prakash KM, Shih YC, Lee KJ, Tan LCS, Tan EK, Chan LL. Quantitative iron-neuromelanin MRI associates with motor severity in Parkinson's disease and matches radiological disease classification. Frontiers in Aging Neuroscience. 10.3389/fnagi.2023.1287917. 2023 Nov 27;15:1287917. doi:

3. Welton T, Hartono S, Shih YC, Schwarz ST, Xing Y, Tan EK, Auer DP, Harel N., Chan LL. Ultra-High-Field 7T MRI in Parkinson’s Disease: Ready for Clinical Use? A Narrative Review. Quantitative Imaging in Medicine and Surgery. 2023 Nov 1;13(11):7607-7620. doi: 10.21037/qims-23-509.

4. Shih YC, Ooi LQR, Li HH, Allen JC, Hartono S, Welton T, Tan EK, Chan LL. Serial deep gray nuclear DTI changes in Parkinson's disease over twelve years. Frontiers in Aging Neuroscience. 2023 Jun 20;15:1169254. doi: 10.3389/fnagi.2023.

5. Welton T, Hartono S, Shih YC, Lee W, Chai PH, Chong SL, Ng SYE, Chia NSY, Choi X, Heng DL, Tan EK, Tan LCS, Chan LL. Microstructure of Brain Nuclei in Early Parkinson's Disease: Longitudinal Diffusion Kurtosis Imaging. Journal of Parkinson’s Disease. 2023;13(2):233-242. doi: 10.3233/JPD-225095.

6. Welton T, Tan YJ, Saffari SE, Ng SYE, Chia NSY, Yong ACW, Choi X, Heng DL, Shih YC, Hartono S, Lee W, Xu Z, Tay KY, Au WL, Tan EK, Chan LL, Ng ASL, Tan LCS. Plasma Neurofilament Light Concentration Is Associated with Diffusion-Tensor MRI-Based Measures of Neurodegeneration in Early Parkinson's Disease. Journal of Parkinson’s Disease. 2022;12(7):2135-2146. doi: 10.3233/JPD-223414.

7. Shih YC, Tseng WI, Montaser-Kouhsari L. Recent advances in using diffusion tensor imaging to study white matter alterations in Parkinson's disease: A mini review. Frontiers in Aging Neuroscience. 2023 Feb 22;14:1018017. doi: 10.3389/fnagi.2022.1018017.

8. Shih YC, Lin FH, Liou HH, Tseng WI. Seizure Frequency Is Associated with Effective Connectivity of the Hippocampal-Diencephalic-Cingulate in Epilepsy with Unilateral Mesial Temporal Sclerosis. Brain Connectivity. 2021 Aug;11(6):457-470. doi: 10.1089/brain.2020.0835.

9. Koh YH, †Shih YC, Lim SL, Kiew YS, Lim EW, Ng SM, Ooi LQR, Tan WQ, Chung YC, Rumpel H, Tan EK, Chan LL. Evaluation of trigeminal nerve tractography using two-fold-accelerated simultaneous multi-slice readout-segmented echo planar diffusion tensor imaging. European Radiology. 2021 Feb;31(2):640-649. doi: 10.1007/s00330-020-07193-x.

10. Lee NC, Peng WH, Tsai LK, Lu YH, Wang HC, Shih YC, Pung ZX, Hu HY, Hwu WL, Tseng WI, Chien YH. Ultrastructural and diffusion tensor imaging studies reveal axon abnormalities in Pompe disease mice. Scientific Reports. 2020 Nov 19;10(1):20239. doi: 10.1038/s41598-020-77193-w.

11. Chen CL, †Shih YC, Liou HH, Hsu YC, Lin FH, Tseng WI. Premature white matter aging in patients with right mesial temporal lobe epilepsy: A machine learning approach based on diffusion MRI data. Neuroimage Clinical. 2019;24:102033. doi: 10.1016/j.nicl.2019.102033.

12. Tsai TH, Su HT, Hsu YC, Shih YC, Chen CC, Hu FR, Tseng WI. White matter microstructural alterations in amblyopic adults revealed by diffusion spectrum imaging with systematic tract-based automatic analysis. British Journal of Ophthalmology. 2019 Apr;103(4):511-516. doi: 10.1136/bjophthalmol-2017-311733.

13. Shih YC, Tseng CE, Lin FH, Liou HH, Tseng WY. Hippocampal Atrophy Is Associated with Altered Hippocampus-Posterior Cingulate Cortex Connectivity in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis. AJNR American Journal of Neuroradiology. 2017 Mar;38(3):626-632. doi: 10.3174/ajnr.A5039.

14. Chien HY, Gau SS, Hsu YC, Chen YJ, Lo YC, Shih YC, Tseng WY. Altered Cortical Thickness and Tract Integrity of the Mirror Neuron System and Associated Social Communication in Autism Spectrum Disorder. Autism Research. 2015 Dec;8(6):694-708. doi: 10.1002/aur.1484.

15. Chang YL, Chen TF, Shih YC, Chiu MJ, Yan SH, Tseng WY. Regional cingulum disruption, not gray matter atrophy, detects cognitive changes in amnestic mild cognitive impairment subtypes. Journal of Alzheimer’s Disease. 2015;44(1):125-38. doi: 10.3233/JAD-141839.

16. Lin YC, Shih YC, Tseng WY, Chu YH, Wu MT, Chen TF, Tang PF, Chiu MJ. Cingulum correlates of cognitive functions in patients with mild cognitive impairment and early Alzheimer's disease: a diffusion spectrum imaging study. Brain Topography. 2014 May;27(3):393-402. doi: 10.1007/s10548-013-0346-2.